Protein Modification Reagents
Medchemexpress LLC Mal-PEG-mal (MW 2000) | 98.4% | 50 MG
Mal-PEG-mal (MW 2000) is a solid chemical compound primarily used as a PROTAC linker for laboratory applications and in the manufacturing of substances.
- Used as a PROTAC linker
- Suitable for laboratory chemical applications
- Suitable for substance manufacturing
- Solid appearance
- Store at -20°C, sealed, away from moisture
Medchemexpress LLC Methyltetrazine-PEG5-alkyne | 1802907-97-6 | MFCD28334550 | 98.0% | C20H26N4O5 | 10MG
Methyltetrazine-PEG5-alkyne is a PEG-based linker reagent containing a methyltetrazine moiety and a terminal alkyne, intended for bioorthogonal conjugation and PROTAC linker synthesis. Supplied as a high-purity research chemical, it is suitable for click chemistry and bioconjugation workflows and is soluble in DMSO.
- Contains methyltetrazine and terminal alkyne functional groups.
- PEG5 spacer provides flexibility and solubility.
- High purity (98.0%) for reliable experimental results.
- Soluble in DMSO for easy handling and reaction setup.
- Available in small quantities suitable for research workflows.
Medchemexpress LLC Dota-PEG5-azide | 3104986-47-9 | 98.0% | C28H52N8O12 | 50 MG
DOTA-PEG5-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent containing an Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules possessing Alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Functions as a click chemistry reagent
- Contains an azide group
- Enables participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules possessing alkyne groups
- Can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Medchemexpress LLC 2-(2-azidoethoxy)ethyl 4-methylbenzenesulfonate | 182347-24-6 | MFCD27946436 | 99.8% | 285.32 g/mol | C11H15N3O4S | 100 MG
N3-PEG2-Tos (2-(2-azidoethoxy)ethyl 4-methylbenzenesulfonate) is a small polyethylene glycol (PEG) linker bearing an azide functional group and a tosylate leaving group. It is used as a bifunctional building block for introducing an azide handle and for electrophilic substitution during linker and conjugation chemistry. CAS 182347-24-6; molecular weight 285.32 g/mol.
- Provides an azide handle for click chemistry applications.
- Contains a tosylate leaving group for efficient nucleophilic substitution.
- Small PEG spacer improves solubility and linker flexibility.
- Suitable for linker synthesis and bioconjugation workflows.
- Store at -20 °C, protected from light and moisture.
- High purity reported (~99.8%) for research use.
Medchemexpress LLC PC biotin-PEG3-azide | 1937270-46-6 | 97.8% | 825.93 | C35H55N9O12S | 5 MG
PC Biotin-PEG3-azide is a cleavable three-unit polyethylene glycol linker containing a biotin tag and an azide functional group. It is used for antibody-drug conjugate synthesis and bioconjugation via copper-catalyzed or strain-promoted azide-alkyne cycloaddition.
- Cleavable three-unit PEG linker for ADC and conjugation chemistry.
- Azide functional group compatible with CuAAC and SPAAC reactions.
- Biotin tag enables detection and affinity capture.
- High chemical purity suitable for research applications.
- Available in small research quantities (5 mg, 10 mg, larger by quote).
Medchemexpress LLC Mal-amido-PEG8-TFP ester | 1924596-31-5 | C32H44F4N2O13 | 100 MG
Mal-amido-PEG8-TFP ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein. PROTACs function by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Utilized in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Pomalidomide-PEG4-C2-NH2 hydrochloride | 2357105-92-9 | 98.2% | 528.98 | 50 MG
Pomalidomide-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in the synthesis of PROTACs. It is for research use only and not sold to patients.
- E3 ligase ligand-linker conjugate
- Incorporates pomalidomide based cereblon ligand and 4-unit PEG linker
- Used in the synthesis of PROTACs
- Appearance: Solid-liquid mixture
- Color: Light yellow to yellow
Creative Pegworks 4-Arm PEG-Dopamine, MW 20k - 1g
4-Arm PEG-Dopamine has 4 dopamine molecules attached to the four arms through an amide bond. Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. It is an organic chemical of the catecholamine and phenethylamine families. On the chemical side, polydopamine is polymerized dopamine that is formed from a slightly basic dopamine solution in the presence of oxygen, and it is a bioinspired material from adhesive polyphenolic proteins in mussels.
Medchemexpress LLC Alkyne-cRGD | 2665674-77-9 | 99.5% | 713.78 | 1 MG
Alkyne-cRGD is an integrin ligand that can be used in the study of degraders and undergoes copper-catalyzed azide-alkyne cycloaddition reaction.
- Integrin ligand
- Used in the study of degraders
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction
Cayman Chemical AzIdo-dPEG7-amIn 5mg
A heterobifunctional PEGylated linker; contains a reactive NH2 end group, as well as an azide functional group for use in click chemistry reactions; has been used as a linker in the synthesis of bivalent mTOR inhibitors
Cayman Chemical Boc-NH-PEG3-CH2CoH 250mg
A building block; has been used as a linker in the synthesis of PROTACs targeting MEK; has been used as a spacer in the synthesis of radiolabeled probes for dual labeling of tumor integrin αVβ3 and GRPR in tumor tissue in vivo
eMolecules 2322322-23-4 | Medchem Express | Methyltetrazine-amido-PEG5-alkyne | 25mg | 752823145 | HY-141276 | 487.557 | C24H33N5O6
Medchem Express | Etretinate | 10mg | 446273333 | HY-B0797 | 54350-48-0 | MFCD00866624 | 354.490 | C23H30O3
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Cayman Chemical PomalIdomIde 10mg
An inhibitor of cereblon (IC50 = ~3 µM for the human recombinant CRBN-DDB1 complex); inhibits autoubiquitination of CRBN in HEK293T cells expressing CRBN; inhibits proliferation of U266 myeloma cells at 0.1-10 µM; reduces tumor growth in a H929 R10-1 lenalidomide-resistant mouse xenograft model at 3 mg/kg per day when used in combination with dexamethasone